Topics to include DNA and RNA profiling and next-generation sequencing of tumors
San Antonio, TX – Dec 3, 2018 – Significant developments in breast cancer research will be presented by NantHealth (NASDAQ: NH) at the San Antonio Breast Cancer Symposium this week. NantHealth, a leader in breakthrough cancer research and solutions to improve patient care and lower healthcare costs, will discuss the findings of three investigations, which examine the theme of providing oncologists with insights that enable cancer treatment tailored to the individual characteristics of each patient.
The Symposium–which will be held at the Henry B. Gonzalez Convention Center in San Antonio from Dec. 4-8 is designed to provide state-of-the-art information on the experimental biology, etiology, prevention, diagnosis and therapy of breast cancer and premalignant breast disease, to an international audience of academic and private physicians and researchers.
“About 1 in 8 U.S. women or about 12.4% will develop invasive breast cancer over the course of her lifetime. Such staggering statistics make breast cancer research and progress critical,” said Sandeep “Bobby” Reddy MD, Chief Medical Officer, NantHealth. “We are honored to have an integral role at the San Antonio Breast Cancer Symposium, which provides a dynamic forum for interaction, communication, and education for a broad spectrum of researchers, health professionals, and those with a special interest in breast cancer.”
Title: “Germline potentially pathogenic variants in breast cancer intrinsic molecular subtypes are not associated with somatic TMB”
Presenting Author: Elias Obeid, MD, MPH
Senior Author: Christopher Szeto, PhD
Contributors: Sandeep “Bobby” Reddy MD, Lori J. Goldstein, MD, Mary B. Daly, MD, PhD, Stephen C. Benz, PhD and Michael J. Hall, MD, MS
Description: Comprehensive DNA and RNA profiling of 270 patients revealed intrinsic molecular subtypes of breast cancer have significantly distinct profiles of pathogenic germline variants. However, despite some breast cancer subtypes having higher frequency of germline pathogenic variants within DNA-damage repair genes, there is little evidence that these patients have subsequently higher mutational burden within their somatic genomes.
Key Takeaway: Pathogenic germline variants in key DNA damage repair genes such as BRCA1/2 are likely not adequate biomarkers for immune checkpoint therapy response, but are potentially biomarkers of differential tumorigenesis pathways.
Title: “Time-course DNA and RNA profiling of tumors from intra-patient cross-over trial of sequential use of aromatase inhibitors”
Presenting Author: Charles Vaske
Senior Authors: Vessela Kristensen and Jürgen Geisler
Contributors: Rahul Parulkar, Nazli Bahrami, Torill Sauer, Marie Loeng, Berit Gravdehaug, Belal Aljabri, Vahid Bemanian, Jonas Lindstrøm and Torben Lüders
Description: Early analysis from the ongoing NEOLETEXE trial examines a time-series of biopsies taken while transitioning patients from steroidal to non-steroidal aromatase inhibitors (AI) and vice versa. Acquired markers of AI-therapy resistance, and potential markers of sequential therapy sensitization, were explored. Two months after initial therapy, mutational burden decreased and clonality increased, yet by 4mo post-initialization mutations particularly in PIK3CA had repopulated.
Key Takeaway: Switching AI therapies sequentially in a clinical study is a model system to study differences in anti-tumor-effects of AIs. This ongoing trial may lead to a novel strategy to resensitize tumors to hormonal treatment and to elucidate the differences between steroidal and non-steroidal AIs.
Title: “Identification of a neoantigen targeted by tumor-infiltrating lymphocytes in a patient with Her2+ breast cancer”
Presenting Author: Hannah Kranich
Senior Authors: Peter A. Fasching and Anita N. Kremer
Contributors: Andrew Nguyen, Hanna Hübner, Erber Ramona, Judith Bausenwein, Edith D. van der Meijden, Michael P. Lux, Sebastian Jud, Claudia Rauh, John Zachary Sanborn, Stephen C. Benz, Shahrooz Rabizadeh, Matthias W. Beckmann, Andreas Mackensen and Matthias Rübner
Description: In our study, we identify tumor infiltrating T-cells (TILS) that recognize tumor specific mutations (Neoepitopes) found by next-generation sequencing of breast cancer tumors. These identified TILS are further immortalized and characterized to bind the patient’s specific HLA alleles.
Key Takeaway: Identification of TILS recognizing patient specific neoepitopes allow development of personalized medicine in a pre-clinical setting.
Since 1977, the San Antonio Breast Cancer Symposium mission has been to provide state-of-the-art information on breast cancer research. From a one-day regional conference, the Symposium has grown to a five-day program attended by a broad international audience of academic and private researchers and physicians from over 90 countries. For more information visit: https://www.sabcs.org/2018-SABCS-sup-sup.
NantHealth, Inc., a member of the NantWorks ecosystem of companies, uses personalized data to improve patient care and lower healthcare costs. NantHealth leads the way in providing oncologists with insights that enable cancer treatment tailored to the individual characteristics of each patient. NantHealth solutions reduce the cost of care by connecting patient data and streamlining the accurate collection and sharing of that data–starting from a patient’s bedside, extending to payers and providers. NantHealth improves clinical decision support, eliminates unwarranted care and seeks to improve patient outcomes. For more information please visit www.nanthealth.com.
NantOmics, a member of the NantWorks ecosystem of companies, delivers molecular analysis capabilities with the intent of providing actionable intelligence and molecularly driven decision support for cancer patients and their providers at the point of care. NantOmics is the first molecular analysis company to pioneer an integrated approach to unearthing the genomic variants and transcriptomic changes that initiate and drive cancer, by analyzing both normal and tumor cells from the same patient and connecting drugs to DNA to RNA changes in the tumor. NantOmics has a highly scalable cloud-based infrastructure capable of storing and processing thousands of genomes a day. For more information please visit www.nantomics.com.