NantHealth and UHS to jointly deliver genomic and transcriptomic sequencing platform and analytics capabilities, incorporating NantHealth’s intelligent clinical operating system (cOS) to transform cancer care coordination
London AND Southampton, UK 3 JUNE, 2015 – University Hospital Southampton NHS Foundation Trust (UHS) and NantHealth today announced a strategic partnership with the aim of delivering and transforming cancer services using the most advanced molecular genomic and proteomic diagnostics, treatment decision support and unique IT integration capabilities for better informed precision treatment selection and care coordination.
Under the three-year programme, NantHealth will enable UHS to rapidly transport raw data from the sequencing machines to NantHealth’s UK based supercomputing infrastructure through the NantTransporter™, and access NantHealth’s automated NantOmics Analytics Platform (NantContraster™) for genomics sequencing interpretation and annotation. In addition, NantHealth will generate rapid and timely clinical reporting to support personalised treatment decision making for cancer patients, based on evidence-based outcomes among patients with a similar genetic signature.
With this partnership UHS will integrate advanced genomic and proteomic capabilities into its existing laboratory and with their agreement engage cancer patients to provide genome samples for sequencing. The enormous volumes of data generated will be quickly processed via NantHealth’s hyper secure UK data centre. It will then utilise comprehensive clinical data to identify potential clinical trial participants for recruitment into targeted trials.
Using NantHealth’s intelligent clinical operating system (cOS), the organisations will work to incorporate NantHealth’s technology platforms to capture relevant cancer clinical and outcomes data from the Trust. This strategic collaboration will help identify future patients suitable for clinical trials at the earliest possible stage and will record outcomes delivered as a result of therapy decisions that are made, in this era of targeted therapy and immuno-oncology. By converging molecular science, computer science and real world big data infrastructure capabilities, the cOS platform will empower providers, patients and commissioners to coordinate the best possible care, monitor outcomes and control cost in real-time.
UHS will join a growing number of leading organisations converging as part of a global network of care providers, commissioners and employers supporting the Omics Network, a collaboration to forge a new area of cancer care discovery and enhance the science of care delivery for the benefit of everyone.
“As an accredited NHS Genomic Medicine Centre, this partnership with NantHealth will allow us to take an important next step in the use of molecular medicine for the benefit of our cancer patients across the Wessex region,” said Fiona Dalton, chief executive officer at University Hospital Southampton NHS Foundation Trust (UHS). “We are proud to be amongst the first organisations not just in the UK but globally to deliver precision diagnostics alongside guided cancer decision support to deliver integrated care delivery solutions. We believe this will facilitate an elevated standard-of-care for our patients and will enable UHS to be at the forefront of specialist cancer services and clinical science in the UK.”
“We are excited at the prospect of working closely with University Hospital Southampton, and together taking from ‘bench to bedside’ the use of whole genome sequencing and proteomics for the benefit of cancer patients in the UK,” said Dr. Patrick Soon-Shiong, founder and CEO of NantHealth. “Our advanced technologies will enable the processing of ‘Real World Big Data,’ in the timely workflow of genomic medicine, and at last allow the promise of science to reach the hands of treating clinicians in time of need. The shared goal of UHS and NantHealth is to modernise and drastically improve the delivery of effective cancer care, in this evolutionary era of targeted and immunotherapy.”
ENDS
Notes to editors
1) University Hospital Southampton NHS Foundation Trust is one of the largest acute teaching trusts in England, with an annual spend of £572 million at three sites across the city of Southampton. It provides hospital services for 1.9 million people living in Southampton and southern Hampshire and specialist services including neurosciences, respiratory medicine, cancer, cardiovascular, obstetrics and specialist children’s services to more than 3.7 million people in central southern England and the Channel Islands.
2) Every year more than 9,500 staff, including nearly 700 consultants, professors and senior lecturers, see 460,000 people at outpatient appointments, deal with 120,000 attendances at the emergency department and treat 140,000 admitted emergency, inpatient or day case patients. In addition, the Trust delivers more than 100 outpatient clinics across the South of England to keep services local for patients. Providing these services costs £1.6 million per day.
3) UHS is fully compliant with all of 16 the Care Quality Commission’s essential standards of quality and safety and has achieved the highest national ranking for safety and management of clinical risks; the NHS Litigation Authority rated the Trust’s performance against standards including governance, safety and clinical care at Southampton General Hospital at level three with a score of 49 out of 50.
4) UHS is consistently one of the UK’s highest recruiting trusts of patients to clinical trials and in the top ten nationally for research study volume as ranked by the NIHR Clinical Research Network. In partnership with the University of Southampton, UHS has £27 million of NIHR infrastructure dedicated to bringing the latest treatments to patients, including the NIHR Southampton Biomedical Research Centre in nutrition, NIHR Southampton Respiratory Biomedical Research Unit, NIHR/Wellcome Trust Clinical Research Facility and NIHR/CRUK Southampton Experimental Cancer Medicine Centre. In addition, the Trust is home to the Southampton Cancer Research UK Centre and MRC Lifecourse Epidemiology Unit.
5) UHS has launched its vision for Southampton Children’s Hospital, a £70 million development that will bring all UHS paediatric services under one roof for the first time. The project is underway and is due for completion in 2020.
6) To help shape the future of hospital services and raise issues that are important to patients, families and visitors, become a UHS member. Anyone interested in finding out more or joining can contact the membership office via 023 8120 4853 or www.uhs.nhs.uk/members. Follow us on Twitter at http://twitter.com/uhsft for all the latest news updates.
For more information contact the communications team on 023 8120 8756.
About NantHealth
NantHealth, a member of the NantWorks ecosystem of companies, is a healthcare transformational cloud-based IT company converging science and technology through a single integrated clinical platform, to provide actionable health information at the point of care, in the time of need, anywhere, anytime. NantHealth works to transform clinical delivery with actionable clinical intelligence at the moment of decision, enabling clinical discovery through real-time machine learning systems. The company’s technology empowers clinicians, patients and researchers to transcend the traditional barriers of today’s healthcare system. By converging molecular science, near real-time patient signal monitoring, computer science and big data technology, the NantHealth Clinical Operating System (cOS) platform empowers providers, patients, and commissioners to coordinate best care, monitor outcomes and control cost in real-time. This is the first system of its kind in healthcare, enabling 21st century coordinated care at a lower cost, enabling value-based population health management at a single patient level and at the population at large. For more information please visit www.nanthealth.co.uk
About NantOmics
NantOmics, a member of the NantWorks ecosystem of companies, delivers medical diagnostics capabilities with the intent of providing actionable intelligence and molecularly driven decision support for cancer patients and their providers at the point of care. NantOmics is the first molecular diagnostics company to pioneer an integrated approach to unearthing the genomic and proteomic variances that initiate and drive cancer, by analysing both normal and tumour cells from the same patient and following identified variances through from DNA to RNA to protein to drug. NantOmics has a highly scalable cloud-based infrastructure capable of storing and processing thousands of genomes a day, computing genomic variances in near real-time, and correlating proteomic pathway analysis with quantitative multi-plexed protein expression analysis from the same micro-dissected tumour sample used for genomic analysis. For more information please visit www.nantomics.com.
About NantTransporter
Data transfer is one of the largest challenges associated with the analysis of sequencing data. NantOmics has designed an infrastructure capable of storing and processing thousands of genomes a day quickly and securely. Our NantTransporter software application enables secure transport of data directly from sequencing machines to NantOmics’s secure private genome processing cloud. Data streams are encrypted using 128-bit Advanced Encryption Standard (AES-128), the same algorithms designated for Top Secret government documents. Initiating a transfer is as easy as obtaining a transfer code from our web site, and specifying the files to be sent. Annotation of the genomes begins immediately with no downtime between transferring and the beginning of processing.
NantWorks has built a dark fiber network capable of Tb/sec transfers between hospitals, academic institutions and sequencing centers. In July 2012 we demonstrated the capabilities of NantTransporter by transferring 94 TB of genomic data and achieved speeds of up to 9.55 Gb/sec with a sustained rate of over 8.232 Gb/sec, the fastest and largest documented transfer of genomic data to date. To date we have transported over 15,000 cancer genomes via NantTransporter.
About NantContraster
Accurately assessing the state of a patient’s genome is one of the most powerful tools in the emerging field of personalized medicine. NantOmics applies its leading, novel genomic analyses to rapidly discover variants in a patient’s raw genomics data using the latest sequencing technologies combined with advanced statistics and machine learning techniques.
NantContraster annotates all variants against a knowledge database comprising all known and probable disease-associated genes to rank the genomic alterations that have the highest clinical relevance. When applied to cancer tumor/normal samples, our analysis is capable of quickly identifying genomic alterations that could lead to tumorigenesis for a fraction of the cost of conventional approaches. NantContraster is capable of concurrently processing many samples to handle large workflows from researchers and hospital settings.
About NantCancer Genome Browser
NantOmics, NantCancer Genome Browser enables clinicians for the first time to investigate a tumor genome from the full three billion bases down to the single-base level in real-time, thanks to the power of the NantOmics supercomputing and secure mobile infrastructure. The Cancer Genome Browser integrates with NantHealth’s treatment recommendation engine, Eviti, to personalize treatment protocols and clinical trail selection to individual patients based on their genomic and transcriptomic signature. The NantCancer Genome Browser is fully encrypted to allow deployment in a HIPAA secured environment, enabling clinicians to securely access patient data as soon as it’s available, wherever they are.
Media Contacts:
UK: Laura Steward, NantHealth | [email protected]
US: Jen Hodson, NantWorks | [email protected]